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Terahertz in the Pharmaceutical Industry

TeraView has successfully applied its proprietary terahertz imaging and spectroscopy technology to increase pharmaceutical product and process understanding as an effective part of the quality by design initiative.

Our systems utilize 3D Terahertz Pulsed Imaging ( TPI™) to nondestructively estimate critical quality attributes in pharmaceutical products such as crystalline structure, thickness and chemical composition. TeraView Pharma Innovations team has demonstrated terahertz instruments produce 3D coating thickness maps for multiple coating layers and structural features models allowing better understanding and control of product scale up and manufacture. The analytical performance of 3D TPI™ measurements is equivalent or better than traditional techniques

Terahertz Pharma Applications:

Solid Dosage Analysis of Tablets

Determine heterogeneity and integrity of pharmaceutical cores and coatings with terahertz imaging.

Solid Dosage Analysis of Tablets

Tablet Coating Thickness In-line Control

Monitor and control in-line pharmaceutical products for better understanding of product and process design.

Tablet Coating Thickness In-line Control

Crystalline Structure Analysis of Drugs

Investigate the crystalline state of drugs with terahertz spectroscopy and understand the dynamics of polymorphic interconversion.

Crystalline Structure Analysis of Drugs

Once in manufacture, TeraView is uniquely positioned to offer 21CFR part 11 compliant terahertz instruments to monitor and ensure compliant product. Recent advances in TeraView technology has demonstrated its capability to non-destructively collect information at speed from tablets in random motion to ultimately be used for in-line control. Working with our TeraView Pharma Innovations team we can develop predictive models that allow you to speed your product through R&D and successful product transfer.

The active use of terahertz technology has recently been supported by the US Food and Drug Administration (FDA) who commented that "the speed and ease of terahertz imaging may make it an attractive potential replacement for wet dissolution testing both in product development and eventually for process analysis" (Spencer, J.A., J Pharm Sci 2007).

THz Pharma Applications

Other THz Applications

Innovations Support

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